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Sitagliptin was not mutagenic or clastogenic with or without metabolic activation in the Ames bacterial mutagenicity assay, a Chinese hamster ovary (CHO) chromosome aberration assay, an in vitro cytogenetics assay in CHO, an in vitro rat hepatocyte DNA alkaline elution assay, and an in vivo micronucleus assay
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or donation or loss of 500 ml (1 pint) of blood within 8 weeks prior to screening or plasma donation of 600 ml within 14 days prior to screening
Patients with advanced type 2 diabetes on insulin Both oral and injection semaglutide were effective in reducing body weight in patients with advanced, uncontrolled type 2 diabetes already on insulin therapy
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