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New research shows that eating animal products causes animal sugars, such as Neu5Gc, to become attached to cells that line our hollow organs, like the stomach, causing the body to make antibodies against these sugars resulting in chronic inflammation and, therefore, impaired B12 absorption
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In addition, the treatment of nicotinamide (NAM), a form of vitamin B3, suppressed the activity of sirtuin-1 (SIRT1), a regulator of cellular stress resistance, and peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1), a key transcriptional coactivator involved in mitochondrial biogenesis and energy metabolism
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