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Cancer history: Growth-promoting peptides require caution in those with cancer history
Moreover, phenformin, at non-cytotoxic concentrations, had also an indirect anti-cancer effect through modulation of the chemokine milieu within the thyroid tumor microenvironment (inhibition of CXCL8 secretion) (Rotondi et al., 2018)
Quality and extent of evidence Key limitations and criticisms Balanced assessment For EPP, the evidence base is moderatetostrong: two highquality RCTs demonstrate clinically meaningful gains in sunlight tolerance and QoL, corroborated by prospective cohorts and PASS data with generally mild adverse events
Secondly, metformins context-dependent regulation of autophagy and mitophagy remains an area of notable uncertainty
