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The viral hijack of human ACE2 receptor disrupts RAAS activation, upregulates NF-B pathway, triggers cytokine storm, hypertension, cell proliferation, inflammation, and fibrosis, where all elicit detrimental effects on every bodily organ during SARS-CoV-2 infection 635

References Young LS, Rickinson AB

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Amanda Kahn expressed her particular interest in MOTS-c because of its "potential role in mitochondrial biology and metabolic health," as mitochondrial dysfunction is associated with aging and many chronic diseases