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Additionally, LC regulates pyruvate dehydrogenase activity through its reaction with acetyl-CoA, as well as proteolysis and protein synthesis necessary for maintaining the protein balance in skeletal muscle
Even people who do not consider themselves "athletes" can tear a meniscus
One potential mechanism is the Nrf2-ARE pathway, which induces a phase 2 detoxification response that promotes disruption of Nrf2-Keap protein interactions, translocation of Nrf2 to the nucleus, and regulation of target gene expression through the ARE, enhancing cellular defense against oxidative damage (Sharma et al., 2010)
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