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While I lasted only two minutes out of the full three, my husband powered through to the end at an invigorating -170+ degrees

Gastroenterology 123, 16771685

Greater understanding of trial generalizability is needed. In the cross-sectional study, the researchers examined a cohort of 8,767 participants aged 20 years or older from the National Health and Nutrition Examination Survey to determine proportions of those who were met the FDAs label criteria for weight loss treatment and those who met trial exclusion criteria

It was the first study to look at the effectiveness of pills rather than injectables, and while small, it was a double-blind, randomised, parallel-arm trial ie gold standard