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Specifically, in the absence of an orthosteric ligand, compound 2 displayed a strong partial agonism in cAMP response (80% Emax of GLP-1), a weak partial agonism in pERK1/2 and no detectable calcium mobilization response 29,30
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Animal and preliminary human studies indicate that GLP-1RAs may also have neuroprotective properties that could mitigate optic nerve damage (12)
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