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GLP-1(936) depletes docked granules pool The fact that GLP-1(936) remains glucagonostatic regardless of whether glucagon secretion is triggered by low glucose alone, membrane depolarisation or receptor-induced elevation of cAMP suggests it may act late in the secretory process, possibly at the level of exocytosis itself

Buse JB, Drucker DJ, Taylor KL, Kim T, Walsh B, Hu H, Wilhelm K, Trautmann M, Shen LZ, Porter LE

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Constipation develops because reduced food intake and slowed digestion both decrease intestinal transit speed