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These pathways included 2-oxocarboxylic acid metabolism, dicarboxylate metabolism, glycolysis/gluconeogenesis, the tricarboxylic acid cycle, and AMPK signaling, as displayed in Figure 3A
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To facilitate the calculations and analysis, an artificial chimera molecule was built using the X-ray fragments found in subpockets A-C in PDB:6FP4 and PDB:6FTC and connected by a short CH 2 CH 2 linker
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