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The higher vascularity of muscle can lead to a quicker rise in circulating concentrations, which might be advantageous in applications requiring a faster onset of action
Some patients report this is the first time in years they feel "normal" for extended periods
As a secreted protein, BDNF is initially synthesized in the endoplasmic reticulum as a precursor protein, called pre-pro-BDNF, which is cleaved into the pro-BDNF isoform (~ 32 kDa) when translocated to the Golgi apparatus
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