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Dont chug a lot of fluid all at once because that may exacerbate the feeling of fullness and make it harder for you to get the protein you need

0.5 mg once weekly for the next 4 weeks if tolerated 1 mg once weekly for the next 4 weeks if tolerated 1.7 mg once weekly for the next 4 weeks if tolerated Maximum dose of 2.4 mg once weekly ongoing if further dose escalation is required Your healthcare provider titrates the dosage according to your appetite, tolerance, weight changes, and potential of semaglutide side effects while your body gets used to the medication

There is a relatively high discontinuation rate due to gastrointestinal side effects

Shi C, Wang Y, Guo J, Zhang D, Zhang Y, Zhang X and Gong Z (2025) Role of malate dehydrogenase 1 and isocitrate dehydrogenase 1 and their posttranslational modifications in diseases