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Int J Mol Med 20:351358

Those with conditions like IBS, IBD, gastritis, or ulcers often use oral protocols with doses of 0.5 to 1 mg daily to maximize local gastrointestinal exposure

Together, these observations suggest that receptor-level signaling and anti-inflammatory effects alone may be insufficient to produce functional improvement in energy-demanding tissues such as skeletal muscle and brain, where substrate turnover and mitochondrial metabolic throughput are critical determinants of tissue function