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The number that made me write the sentence a decade ago I would have called it fantasy. At the end of that piece I listed what we still needed
Unlike GLP-1, supraphysiologic GIP infusions do not amplify the late phase insulin response to glucose in patients with T2DM ( Native GLP-1 and GIP have limited pharmacologic value because of their short plasma half-life (17 min) ( Leveraging the Incretin Effect for the Treatment of T2DM Because of the apparent lack of beta-cell responsiveness to GIP in patients with poorly controlled T2DM, most therapeutic strategies have focused on enhancing the activity of GLP-1
Glucagon-like peptide-1 receptor agonists (GLP-1RAs) have demonstrated clinically significant cardiovascular and kidney benefits in individuals with type 2 diabetes (T2D) and cardiovascular benefits in those with obesity and atherosclerotic cardiovascular disease at baseline 6,7
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