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GIP signalling appears to modulate how nutrients are handled metabolically and may soften the nausea that pure GLP-1 agonism can provoke
This results in a more gradual rise in blood sugar after meals and can contribute to feelings of fullness
Cold exposure also stimulates brown adipose tissue activation and increases noradrenaline levels, which supports the cellular energy production impaired by Candida's acetaldehyde burden
The available evidence including the STEP 4 withdrawal trial (Rubino et al., JAMA 2021) shows most people regain weight when they stop GLP-1 therapy without a structured maintenance plan
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