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Furthermore, poor solubility poses significant hurdles for formulation development, frequently resulting in low oral bioavailability and necessitating complex nanocarriers or specialized formulations that increase cost and limit administration routes [68,69,70,71]
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Replicating the results becomes impossible
Every Other Day (EOD) Dosing Every other day dosing at slightly higher per-session amounts (e.g., 23 mg EOD instead of 1 mg daily) is also used, particularly to reduce injection frequency or manage cost
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