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[41] [42] The hypothesis that melatonin synthesis occurs within mitochondria and chloroplasts suggests an evolutionary and functional significance of melatonin in cellular energy metabolism and defense mechanisms against oxidative stress, reflecting the molecule's ancient origins and its multifaceted roles across different domains of life

When both receptors are activated simultaneously, the appetite-suppressing and metabolic effects appear to be additive in ways that single-receptor activation doesn't fully replicate

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