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The largest trial of ERAs, SONAR, including 2648 participants with type 2 diabetes and proteinuric CKD, demonstrated that atrasentan on top of RAS inhibition significantly lowered the risk of a doubling of serum creatinine or ESKD compared with placebo by 35% [75]

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AGEs also affect keratinocytes and melanocytes, leading to the thinning of the stratum corneum and to the increased production of melanin