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Among approved drugs, tirzepatide (Mounjaro/Zepbound) produced the largest average weight loss in trials, about 20.9% over 72 weeks at the highest dose in SURMOUNT-1, ahead of semaglutide at roughly 14.9% over 68 weeks in STEP 1
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Olatunji G et al
For instance, Blue Cross and Blue Shields Federal Employee Program Blue Basic Plan has a $15 copay for a 30-day supply of generics and 35% coinsurance for preferred brand-name drugs
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