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High levels of TMAO have been linked to an increased risk of heart disease

In the latest tranche of published warning letters, the US Food and Drug Administration (FDA) has continued to go after drugmakers for marketing glucagon-like peptide-1 (GLP-1) receptor agonists and similar medications without regulatory approval

it also increases the risk of heart disease and type 2 diabetes

However, it is now an established belief among many leaders of research in psychiatry that cytokines (and potentially other inflammatory mediators) released by our immune system during an inflammatory response, cross the blood-brain barrier, enter the brain and trigger the brains immune cells (microglia) to release cytokines in the brain