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This is a major barrier for oral GHK-Cu, significantly reducing how much active peptide reaches systemic circulation

References Sosne G, Qiu P, Kurpakus-Wheater M

Many of the animal studies note that BPC-157 appears to be generally safe

Mikhaleva (1995) Effects of delta-sleep inducing peptide (DSIP) and some analogues on the activity of monoamine oxidase type A in rat brain under hypoxia stress FEBS Letters, Volume 368, Issue 2, 17 July 1995, Pages 367-369