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Common Contraindications Active or recent cancer (BPC-157 and TB-500 angiogenesis concern), Wilson's disease or other copper metabolism disorders (GHK-Cu component), pregnancy or breastfeeding (no safety data for any component), and competitive sport at WADA-tested levels (BPC-157 and TB-500 are listed under WADA category S0 Unapproved Substances) are commonly cited reasons not to research KLOW

However, no randomized trials have evaluated semaglutide or tirzepatide as primary Hashimoto's treatments, and autoimmune responses remain a consideration in any new medication introduction

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