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It works by mimicking the GLP-1 hormone to increase insulin secretion, decrease glucagon release, and slow gastric emptying
Oral semaglutide also provides significant appetite suppression but may take longer to show results
By targeting both GLP-1 and the Glucose-dependent insulinotropic polypeptide (GIP) receptor, it demonstrated a synergistic effect that surpassed GLP-1 mono-agonists
Cells carry more receptors than the machinery downstream can use, so the effect can run near its ceiling while occupancy is still low (the spare-receptor effect). For retatrutide this gap is largest at the GLP-1 receptor, where the concentration that half-fills the appetite signal is roughly nine times lower than the concentration that half-fills the receptor itself
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