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(2022a) found that transforming growth factor receptor 1 (TGFR1) was significantly elevated in LPS/D-GaIN-induced ALF and liver-specific knockout of TGFR1-moderated LPS/D-GaIN triggered ferroptosis and apoptosis by regulating the phosphorylation of Nrf2 and glycogen synthase kinase 3 (GSK3), and by augmenting the expression of ferroptosis-associated proteins, such as GPX4, dihydroorotate dehydrogenase, and ferroptosis suppressor protein 1 (Huang et al., 2022a)
Safety data in humans is very limited
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