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Tissue Repair and Musculoskeletal Recovery
Across trials where participants lost at least 15% of their body weight, lean mass made up roughly 25% of total weight lost on tirzepatide and roughly 39% on semaglutide
External resources PMC: Preservation of Lean Soft Tissue During GLP-1 Weight Loss American Diabetes Association: GLP-1 Therapies and Muscle Preservation For researchers serious about optimizing their GLP-1 protocols and nutrition, SeekPeptides offers the most comprehensive resource available, with evidence-based guides, personalized protocols, and a community of thousands who have navigated these exact questions about what to eat, when to eat it, and how to make every calorie count toward their goals
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